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1

Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration

Perlikowska, Renata, Piekielna, Justyna, Gentilucci, Luca, De Marco, Rossella, Cerlesi, Maria Camilla, Calo, Girolamo, Artali, Roberto, Tömböly, Csaba, Kluczyk, Alicja, Janecka, Anna

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 849 KB

english, 2015

2

Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile

Wtorek, Karol, Artali, Roberto, Piekielna-Ciesielska, Justyna, Koszuk, Jacek, Kluczyk, Alicja, Gentilucci, Luca, Janecka, Anna

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 817 KB

english, 2019

3

Detection of glycation sites in proteins by high-resolution mass spectrometry combined with isotopic labeling

Piotr Stefanowicz, Monika Kijewska, Alicja Kluczyk, Zbigniew Szewczuk

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 953 KB

english, 2010

4

A new procedure for the synthesis of peptide-derived Amadori products on a solid support

Piotr Stefanowicz, Katarzyna Kapczyńska, Alicja Kluczyk, Zbigniew Szewczuk

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

5

HLA-DQ7 β1 and β2 derived peptides as immunomodulators

Theodore Skarlas, Eugenia Panou-Pomonis, Alicja Kluczyk, Zbigniew Szewczuk, Michal Zimecki, Aggeliki Kosmopoulou, Maria Sakarellos-Daitsiotis, Constantinos Sakarellos

Journal:

Journal of Peptide Science

Year:

2009

Language:

english

File:

PDF, 659 KB

english, 2009

6

Microwave-assisted TFA cleavage of peptides from Merrifield resin

Alicja Kluczyk, Magdalena Rudowska, Piotr Stefanowicz, Zbigniew Szewczuk

Journal:

Journal of Peptide Science

Year:

2010

Language:

english

File:

PDF, 270 KB

english, 2010

7

Electrospray ionization mass spectrometric analysis of complexes between peptide-derived Amadori products and borate ions

Monika Kijewska, Alicja Kluczyk, Piotr Stefanowicz, Zbigniew Szewczuk

Journal:

Rapid Communications in Mass Spectrometry

Year:

2009

Language:

english

File:

PDF, 531 KB

english, 2009

8

Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines

Małgorzata Koprowska-Ratajska, Alicja Kluczyk, Piotr Stefanowicz, Hubert Bartosz-Bechowski, Zbigniew Szewczuk

Journal:

Year:

2009

Language:

english

File:

PDF, 282 KB

english, 2009

9

The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization

Katarzyna Kapczyńska, Piotr Stefanowicz, Łukasz Jaremko, Mariusz Jaremko, Alicja Kluczyk, Zbigniew Szewczuk

Journal:

Year:

2011

Language:

english

File:

PDF, 567 KB

english, 2011

10

Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin

Alicja Kluczyk, Marzena Cydzik, Monika Biernat, Remigiusz Bąchor, Paweł Pasikowski, Piotr Stefanowicz, Jolanta Artym, Michał Zimecki, Zbigniew Szewczuk

Journal:

Journal of Peptide Science

Year:

2012

Language:

english

File:

PDF, 410 KB

english, 2012

11

The Hydrogen–Deuterium Exchange at α-Carbon Atom inN,N,N-Trialkylglycine Residue: ESI-MS Studies

Magdalena Rudowska, Dominika Wojewska, Alicja Kluczyk, Remigiusz Bąchor, Piotr Stefanowicz, Zbigniew Szewczuk

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2012

Language:

english

File:

PDF, 236 KB

english, 2012

12

The isotopic exchange of oxygen as a tool for detection of the glycation sites in proteins

Monika Kijewska, Piotr Stefanowicz, Alicja Kluczyk, Zbigniew Szewczuk

Journal:

Analytical Biochemistry

Year:

2011

Language:

english

File:

PDF, 868 KB

english, 2011

13

Effect of 2′,6′-dimethyl-l-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs

Jakub Fichna, Renata Perlikowska, Anna Wyrębska, Katarzyna Gach, Justyna Piekielna, Jean Claude do-Rego, Geza Toth, Alicja Kluczyk, Tomasz Janecki, Anna Janecka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 456 KB

english, 2011

14

The immunomodulatory diversity of the proteins of the transforming growth factor β (TGFβ) family

ZBIGNIEW WIECZOREK, JACEK SŁOń, ALICJA KLUCZYK, RENATA ZBOZIEń, PIOTR STAFANOWICZ, IGNACY Z. SIEMION

Journal:

Chemical Biology & Drug Design

Year:

1995

Language:

english

File:

PDF, 515 KB

english, 1995

15

The “two-headed” peptide inhibitors of interleukin-1 action

Alicja Kluczyk, Ignacy Z. Siemiona, Zbigniew Wieczorek

Journal:

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

16

The immunosuppressive activity of peptide fragments of vaccinia virus C10L protein and a hypothesis on the role of this protein in the viral invasion

Alicja Kluczyk, Ignacy Z Siemion, Zbigniew Szewczuk, Zbigniew Wieczorek

Journal:

Year:

2002

Language:

english

File:

PDF, 267 KB

english, 2002

17

Tuftsin: On the 30-year anniversary of Victor Najjar’s discovery

Ignacy Z. Siemion, Alicja Kluczyk

Journal:

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

18

Sensitive electrospray mass spectrometry analysis of one-bead-one-compound peptide libraries labeled by quaternary ammonium salts

Bąchor, Remigiusz, Cydzik, Marzena, Rudowska, Magdalena, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Molecular Diversity

Year:

2012

Language:

english

File:

PDF, 265 KB

english, 2012

19

Geometric changes around an N atom due to a urethane-type bis( tert -butoxycarbonyl) substituent

Wojewska, Dominika, Kluczyk, Alicja, Ślepokura, Katarzyna

Journal:

Acta Crystallographica Section C Crystal Structure Communications

Year:

2013

Language:

english

File:

PDF, 943 KB

english, 2013

20

Drug Evolution Concept in Drug Design: 1. Hybridization Method †

Lazar, Carmen, Kluczyk, Alicja, Kiyota, Taira, Konishi, Yasuo

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

21

New method of peptide cleavage based on Edman degradation

Remigiusz Bąchor, Alicja Kluczyk, Piotr Stefanowicz…

Journal:

Molecular Diversity

Year:

2013

Language:

english

File:

PDF, 308 KB

english, 2013

22

Impact of Micelle Ionic Electrical Double Layer Structure on the Excited State Protolytic Reaction in the Fluorescent Probe Bound to the Colloidal Nanoparticles

Jankowski, Andrzej, Wiśniewski, Łukasz, Jankowski, Adam, Kluczyk, Alicja, Chmielewski, Piotr, Szemik-Hojniak, Anna

Journal:

Journal of Physical Chemistry B

Year:

2011

Language:

english

File:

PDF, 2.03 MB

english, 2011

23

Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues

Perlikowska, Renata, Malfacini, Davide, Cerlesi, Maria Camilla, Calo’, Girolamo, Piekielna, Justyna, Floriot, Léonore, Henry, Tiphaine, do-Rego, Jean Claude, Tömböly, Csaba, Kluczyk, Alicja, Janecka,

Journal:

Year:

2014

Language:

english

File:

PDF, 534 KB

english, 2014

24

Cyclic pentapeptide analogs based on endomorphin-2 structure: Cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry

Piekielna, Justyna, Kluczyk, Alicja, Perlikowska, Renata, Janecka, Anna

Journal:

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

25

Selective Detection of Carbohydrates and Their Peptide Conjugates by ESI-MS Using Synthetic Quaternary Ammonium Salt Derivatives of Phenylboronic Acids

Kijewska, Monika, Kuc, Adam, Kluczyk, Alicja, Waliczek, Mateusz, Man-Kupisinska, Aleksandra, Lukasiewicz, Jolanta, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2014

Language:

english

File:

PDF, 850 KB

english, 2014

26

The unusual hydrogen-deuterium exchange of α -carbon protons in N -substituted glycine-containing peptides

Bąchor, Remigiusz, Setner, Bartosz, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Journal of Mass Spectrometry

Year:

2014

Language:

english

File:

PDF, 448 KB

english, 2014

27

Microwave-assisted 18 O labeling of Fmoc-protected amino acids

Modzel, Maciej, Płóciennik, Halina, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Journal of Peptide Science

Year:

2014

Language:

english

File:

PDF, 334 KB

english, 2014

28

Hydrogen-deuterium exchange of α-carbon protons and fragmentation pathways in N-methylated glycine and alanine-containing peptides derivatized by quaternary ammonium salts

Bąchor, Remigiusz, Rudowska, Magdalena, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Journal of Mass Spectrometry

Year:

2014

Language:

english

File:

PDF, 748 KB

english, 2014

29

Comparison of modification sites in glycated crystallin in vitro and in vivo

Kielmas, Martyna, Kijewska, Monika, Kluczyk, Alicja, Oficjalska, Jolanta, Gołębiewska, Bożena, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Analytical and Bioanalytical Chemistry

Year:

2015

Language:

english

File:

PDF, 521 KB

english, 2015

30

Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines

Piekielna, Justyna, Perlikowska, Renata, do-Rego, Jean Claude, do-Rego, Jean-Luc, Cerlesi, Maria Camilla, Calo, Girolamo, Kluczyk, Alicja, Łapiński, Krzysztof, Tömböly, Csaba, Janecka, Anna

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 470 KB

english, 2015

31

Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity

Piekielna, Justyna, Kluczyk, Alicja, Gentilucci, Luca, Cerlesi, Maria Camilla, Calo’, Girolamo, Tomböly, Csaba, Łapiński, Krzysztof, Janecki, Tomasz, Janecka, Anna

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 591 KB

english, 2015

32

Ubiquitin fragments: their known biological activities and putative roles

Pasikowski, Paweł, Cydzik, Marzena, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

BioMolecular Concepts

Year:

2010

Language:

english

File:

PDF, 355 KB

english, 2010

33

Drug Evolution: p-Aminobenzoic Acid as a Building Block

Kluczyk, Alicja, Popek, Tomasz, Kiyota, Taira, de Macedo, Pierre, Stefanowicz, Piotr, Lazar, Carmen, Konishi, Yasuo

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 547 KB

english, 2002

34

Facile synthesis of deuterium-labeled denatonium cation and its application in the quantitative analysis of Bitrex by liquid chromatography-mass spectrometry

Bąchor, Remigiusz, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Analytical and Bioanalytical Chemistry

Year:

2015

Language:

english

File:

PDF, 898 KB

english, 2015

35

Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs

Adamska, Anna, Kluczyk, Alicja, Cerlesi, Maria Camilla, Calo, Girolamo, Janecka, Anna, Borics, Attila

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

36

Correction for “Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines”

Piekielna, Justyna, Perlikowska, Renata, do-Rego, Jean-Claude, do-Rego, Jean-Luc, Cerlesi, Maria Camilla, Calo, Girolamo, Kluczyk, Alicja, Łapiński, Krzysztof, Tömböly, Csaba, Janecka, Anna

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 125 KB

english, 2016

37

Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N -methylated amino acid residues

Adamska, Anna, Kolesińska, Beata, Kluczyk, Alicja, Kamiński, Zbigniew J., Janecka, Anna

Journal:

Journal of Peptide Science

Year:

2015

Language:

english

File:

PDF, 226 KB

english, 2015

38

Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates

Bąchor, Remigiusz, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Journal of Peptide Science

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

39

Effect of neutral salts on the excited state proton transfer in the fluorescent probe anchored to the uncharged micelles

Jankowski, Andrzej, Jankowski, Adam, Kluczyk, Alicja, Szemik-Hojniak, Anna

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

40

Cyclodimerization of immunosuppressive fragment of HLA-DR molecule. Design, synthesis and ESI-MS/MS analysis

Biernat, Monika, Cydzik, Marzena, Stefanowicz, Piotr, Kluczyk, Alicja, Artym, Jolanta, Zimecki, Michał, Szewczuk, Zbigniew

Journal:

Journal of Peptide Science

Year:

2016

Language:

english

File:

PDF, 578 KB

english, 2016

41

Cyclic mu-opioid receptor ligands containing multiple N -methylated amino acid residues

Adamska-Bartłomiejczyk, Anna, Janecka, Anna, Szabó, Márton Richárd, Cerlesi, Maria Camilla, Calo, Girolamo, Kluczyk, Alicja, Tömböly, Csaba, Borics, Attila

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 961 KB

english, 2017

42

Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold

Adamska-Bartłomiejczyk, Anna, De Marco, Rossella, Gentilucci, Luca, Kluczyk, Alicja, Janecka, Anna

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

43

The 5-azoniaspiro[4.4]nonyl group for improved MS peptide analysis: A novel non-fragmenting ionization tag for mass spectrometric sensitive sequencing of peptides

Setner, Bartosz, Rudowska, Magdalena, Kluczyk, Alicja, Stefanowicz, Piotr, Szewczuk, Zbigniew

Journal:

Analytica Chimica Acta

Year:

2017

Language:

english

File:

PDF, 841 KB

english, 2017

44

Synthesis and activity of opioid peptidomimetics with β 2 - and β 3 -amino acids

Gach-Janczak, Katarzyna, Piekielna-Ciesielska, Justyna, Adamska-Bartłomiejczyk, Anna, Perlikowska, Renata, Kruszyński, Rafał, Kluczyk, Alicja, Krzywik, Julia, Sukiennik, Jarosław, Cerlesi, Maria Camil

Journal:

Year:

2017

Language:

english

File:

PDF, 735 KB

english, 2017

45

Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis -4-amino-L-proline residues

Adamska-Bartłomiejczyk, Anna, Borics, Attila, Tömböly, Csaba, Dvorácskó, Szabolcs, Lisowski, Marek, Kluczyk, Alicja, Wołczański, Grzegorz, Piekielna-Ciesielska, Justyna, Janecka, Anna

Journal:

Journal of Peptide Science

Year:

2017

Language:

english

File:

PDF, 365 KB

english, 2017

46

Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors

Wtorek, Karol, Adamska-Bartłomiejczyk, Anna, Piekielna-Ciesielska, Justyna, Ferrari, Federica, Ruzza, Chiara, Kluczyk, Alicja, Piasecka-Zelga, Joanna, Calo’, Girolamo, Janecka, Anna

Journal:

Year:

2019

File:

PDF, 2.44 MB

2019

47

Pharmacological profile and molecular modeling of cyclic opioid analogs incorporating various phenylalanine derivatives

Adamska-BartÅomiejczyk, Anna, LipiÅski, Piotr F. J., Piekielna-Ciesielska, Justyna, Kluczyk, Alicja, Janecka, Anna

Journal:

Year:

2020

File:

PDF, 1.49 MB

2020

48

Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore

Sarkar, Arijit, Adamska-Bartlomiejczyk, Anna, Piekielna-Ciesielska, Justyna, Wtorek, Karol, Kluczyk, Alicja, Borics, Attila, Janecka, Anna

Journal:

Year:

2020

File:

PDF, 2.84 MB

2020

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